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 18 February 2018

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News

Low-dose growth hormone in short bowel syndrome patients

Researchers from France find that low-dose growth hormone improves intestinal absorption in home parenteral nutrition-dependent short bowel syndrome patients.

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High-dose (0.14mg per kg per day) growth hormone (GH), glutamine, and high carbohydrate diet in home parenteral nutrition (HPN)-dependent patients with short-bowel syndrome (SBS), is controversial.

In this study, researchers assessed treatment with low-dose GH in these patients.

Growth hormone increased intestinal absorption of energy, nitrogen, carbohydrates, and fat.
Gastroenterology
Their findings are published in the February issue of Gastroenterology.

The researchers randomized 12 adult HPN-dependent patients with SBS on an unrestricted hyperphagic diet in a double-blind, placebo-controlled, crossover study.

Patients received daily low-dose GH (0.05 mg per kg per day), and placebo for two 3-week periods, separated by a 1-week washout period.

The team assessed net intestinal absorption of macronutrients using a duplicate diet. In addition, nutritional assessment and blood tests were performed.

The team compared data from each group using Wilcoxon rank sum test.

The researchers found that treatment with GH increased intestinal absorption of energy, nitrogen, carbohydrates, and fat.

Furthermore, the increased food absorption represented 37% of total parenteral energy delivery.

Body weight, lean body mass, D-xylose absorption, insulin-like growth factor 1, and insulin-like growth factor binding protein 3 all increased.

However, uptake of GH binding protein decreased, but without any major adverse effect.

Dr David Seguy’s team concluded, “Three weeks of low-dose GH significantly improved intestinal absorption in HPN-dependent SBS patients who were on a hyperphagic western diet”.

Gastroenterology 2003; 124(2): 293-302
03 February 2003

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