In this study, researchers from France evaluated 5-year survival predictive factors in hospitalized patients with excessive alcohol intake and cirrhosis.
They included a multivariate analysis the severity of the liver disease, GI bleeding, viral B or C infection, smoking status, presence of alcoholic hepatitis at inclusion, and abstinence from alcohol during follow-up.
The research team performed a non-concurrent cohort study.
They included 122 patients with excessive alcohol intake and cirrhosis, who were followed-up for at least 5 years, or until death.
Throughout the course of the study, 2 patients were lost to follow-up.
The research team found that the 5-year survival rate was 43% overall.
|Overall 5-year survival rate was 43%.|
However, in Child-Pugh classes A, B, and C survival rates were 66%, 50%, and 25%, respectively.
Using multivariate analysis, the team found that age, Child-Pugh score, GI bleeding, presence of HBs Ag and/or anti-HCV, smoking, absence of histologically proven alcoholic hepatitis, and persistent alcohol intake were associated with an increased risk ratios of death.
Dr Pessione's team concluded, "In hospitalized patients with excessive alcohol intake and cirrhosis…age, liver failure, gastrointestinal bleeding, concomitant viral B or C infection and persistent alcohol intake are independent poor prognostic markers".
In addition, "Smoking may contribute to the aggravation of cirrhosis".
However, "Alcoholic hepatitis, being a potentially reversible cause of liver failure, has a favorable prognostic significance".