In this study, a team of researchers from Japan performed a retrospective cohort study to investigate early and late phase recurrence of hepatocellular carcinoma (HCC).
They assessed 249 patients, including 157 with cirrhosis, who underwent hepatectomy for HCC.
The team set the endpoint of the study, as time-to-recurrence.
|Factors contributing to early recurrence:|
- non-anatomical resection
- microscopic vascular invasion
- alpha-fetoprotein level
|Journal of Hepatology|
They performed a Cox regression model to investigate factors to early and late phase recurrences.
The researchers found that the actuarial probability of overall recurrence at 1, 3, and 5 years was 0.301, 0.623, and 0.790, respectively, with a median follow-up of 624 days.
The team observed early recurrence in 123 out of 249 patients.
Late recurrence was found in 61 of 113 patients.
They determined factors contributing to early recurrence as non-anatomical resection, presence of microscopic vascular invasion, and serum alpha-fetoprotein level 32ng/ml.
However, factors contributing to late phase recurrence were higher grade of hepatitis activity, multiple tumors, and gross tumor classification.
Dr Hiroshi Imamura’s team concluded, “Variables associated with metastatic recurrence were factors to early phase recurrence”.
“Whereas those related with elevated carcinogenesis contributed to late phase recurrence.”
“Thus providing epidemiological evidence that different mechanisms…are involved in intrahepatic recurrence after hepatectomy for HCC”.