In this study, researchers from Australia determined whether incidence of fatal coronary heart disease and cardiovascular disease is related to serum and red cell folate, and vitamin B-12 concentrations.
The team performed a cohort study with follow up of 29 years in Busselton, Western Australia.
|No independent association was found between folate and B-12 concentrations, and death from coronary heart or cardiovascular disease.|
|British Medical Journal|
Study participants included 1419 men and 1531 women aged 20 to 90 years, who were alive more than 3 years after their participation in the 1969 Busselton health survey. Of these, 78% had no cardiovascular disease at the initial survey.
The team's main outcome measures were hazard ratios for fatal coronary heart disease and cardiovascular disease according to baseline concentrations of serum and red cell folate, and serum vitamin B-12.
The team found that 213 men and 159 women died from coronary heart disease. In addition, 342 men and 302 women died from cardiovascular disease.
Serum and red cell folate concentrations showed a moderate positive correlation, but otherwise concentrations were not strongly correlated with each other, or with other standard risk factors.
Once the team had adjusted for age and standard risk factors, there was no independent association between folate and B-12 concentrations and death from coronary heart disease or cardiovascular disease.
In addition, the multivariate adjusted hazard ratio for death from cardiovascular disease in the lowest versus highest category of red cell folate concentration was 1.05 in men and 1.10 in women.
Dr Joseph Hung's team concluded, "These findings do not support the hypothesis that lower folate and B-12 concentrations increase the risk of fatal cardiovascular disease in a general population".
"The routine use of these vitamins for preventing cardiovascular disease should await evidence from clinical trials."