In this study, published in the Canadian Journal of Anesthesia, researchers sought to determine the effects of desmopressin on coagulation and blood loss in patients undergoing elective partial hepatectomy.
The research team performed a randomized, controlled and double-blind study on 59 patients who received either 0.3 µg•kg-1 of desmopressin, or an equal volume of normal saline.
Treatments were infused intravenously over 20 min after induction of general anesthesia.
The researchers found a significant increase in plasma levels of factors VIII and von Willebrand, after the infusion of study drug in both groups.
The team also observed a wide range of intraoperative blood loss (400 to 7128 ml), with no significant differences between groups.
In addition, there were no changes in plasma electrolyte levels or osmolality.
|No significant difference in intraoperative blood loss between groups.|
|Canadian Journal of Anesthesia|
Transfusion requirements were similar in both groups.
Dr Andrew Wong's team concluded, "Desmopressin did not reduce intraoperative blood loss or transfusion requirements during hepatectomy despite raising clotting factor levels and improving tests of hemostasis".