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 23 November 2017

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News

Long-term survival after extended resections in patients with gallbladder cancer

In patients with gallbladder cancer, curative status can be achieved in only 43% of patients undergoing extended resections, find researchers in the January issue of the Journal of the American College of Surgeons.

News image

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Surgery is the treatment of choice for gallbladder cancer, however the extent of resection and its benefits remain unclear.

In this study, a team of researchers from India, performed a survival analysis of 42 patients who had undergone extended resections for gallbladder cancer.

The team labeled resections either R0 (curative) or R1 (noncurative) based on histopathologic evaluation.

Patients with node negative disease had significantly better survival than those with node positive disease.
Journal of the American College of Surgeons

The researchers also constructed survival curves using the Kaplan-Meier method.

In addition, survival data were analyzed, using univariate and multivariate analyses, in order to identify factors associated with long-term (>2 years) survival.

R0 status was achieved in 43% of patients: 100%, 100%, 45%, and 0% in stages I, II, III, and IV, respectively.

The team found that patients who had R0 resections had a significantly better survival than those with R1 resections.

In addition, R0 status was achieved in only 3 of 20 patients with node positive (N1) disease, compared with 14 of 17 patients with node negative (N0) disease.

The team also determined that patients with N0 disease had a significantly better survival than those with N1 disease.

The researchers found that none of the patients with N1 disease survived 5 years, however 5-year survival for N0 patients was 58%.

Furthermore, adjuvant therapy did not have a significant effect on survival.

Dr Anu Behari's team concluded, "In patients with gallbladder cancer, R0 status could be achieved in only 43% of patients undergoing extended resections".

"R0 status and N0 disease were associated with better long-term survival".

J Am Coll Surg Volume 2003; 196(1): 82-88
07 January 2003

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