Surgery is the treatment of choice for gallbladder cancer, however the extent of resection and its benefits remain unclear.
In this study, a team of researchers from India, performed a survival analysis of 42 patients who had undergone extended resections for gallbladder cancer.
The team labeled resections either R0 (curative) or R1 (noncurative) based on histopathologic evaluation.
|Patients with node negative disease had significantly better survival than those with node positive disease.
|Journal of the American College of Surgeons|
The researchers also constructed survival curves using the Kaplan-Meier method.
In addition, survival data were analyzed, using univariate and multivariate analyses, in order to identify factors associated with long-term (>2 years) survival.
R0 status was achieved in 43% of patients: 100%, 100%, 45%, and 0% in stages I, II, III, and IV, respectively.
The team found that patients who had R0 resections had a significantly better survival than those with R1 resections.
In addition, R0 status was achieved in only 3 of 20 patients with node positive (N1) disease, compared with 14 of 17 patients with node negative (N0) disease.
The team also determined that patients with N0 disease had a significantly better survival than those with N1 disease.
The researchers found that none of the patients with N1 disease survived 5 years, however 5-year survival for N0 patients was 58%.
Furthermore, adjuvant therapy did not have a significant effect on survival.
Dr Anu Behari's team concluded, "In patients with gallbladder cancer, R0 status could be achieved in only 43% of patients undergoing extended resections".
"R0 status and N0 disease were associated with better long-term survival".