Previous studies have shown that appendectomy is associated with a low risk of subsequent ulcerative colitis.
In this study, researchers from Sweden and the United States analyzed the risk of Crohn's disease following appendectomy.
The research team followed up 212,218 patients with appendectomy before age 50 years, plus a cohort of matched controls.
The team identified the 212,218 study subjects from the Swedish Inpatient Register and the nationwide Census.
Any development of Crohn's disease, following appendectomy, was recorded.
|There is and increased risk of Crohn's disease for more than 20 years after appendectomy.|
The team found that there was an increased risk of Crohn's disease for more than 20 years after appendectomy.
They calculated incidence rate ratios of 2.11 after perforated appendicitis, 1.85 after nonspecific abdominal pain, 2.15 after mesenteric lymphadenitis, and 2.52 after other diagnoses.
Following nonperforated appendicitis, there was an increased risk among women but not among men.
However, the team also found that patients operated on before age 10 years had a low risk of Crohn's disease.
Furthermore, Crohn's disease patients with a history of perforated appendicitis had a worse prognosis.
Dr Roland Andersson's team concluded, "Appendectomy is associated with an increased risk of Crohn's disease that is dependent on the patient's sex, age, and the diagnosis at operation".
"The pattern of associations suggests a biologic cause".