Crohn's disease (CD) is a chronic transmural inflammatory disease of unknown etiology.
It is thought that genetic background may influence the nature of disease.
The Jewish population in Israel is composed of Ashkenazi and Sephardic Jews, who differ in their genetic background.
Previous studies have reported that the prevalence of CD in Sephardic Jews is lower than in Ashkenazi Jews.
However, no information is available regarding disease characteristics in these patient populations.
In this study, a research team from Israel assessed the demographic and clinical characteristics of CD in Israeli Jewish patients.
The team studied 189 CD patients.
|Strictures occurred more often in ileal than in colonic disease.|
|Journal of Clinical Gastroenterology|
They collected and analyzed both demographic and clinical data.
The researchers found that 48% of the patients had ileum-only disease.
In addition, fistulizing disease was more frequently seen in ileocolonic, than in ileal or colonic disease.
However, strictures occurred more often in ileal than in colonic disease (22% and 3%, respectively).
The team identified no association between current smoking and disease severity.
The research team also found that Sephardic patients more frequently had extraintestinal disease, than Ashkenazi patients (35% versus 17%, respectively).
Dr Herma Fidder's team concluded, "Jewish Israeli patients show a predilection for ileum-only disease".
"Disease severity appears not to be influenced by smoking".
"These differences in disease behavior may be related to genetic factors".