In this study, published in Blood, researchers have reviewed several complications, following percutaneous liver biopsy, in patients with sickle cell disease.
The team examined 14 patients with sickle cell disease who underwent a percutaneous liver biopsy.
They then correlated clinicopathologic findings with outcome.
|Of the 14 patients, 36% suffered serious hemorrhage.|
The research team found that of the 14 patients, 36% suffered serious hemorrhage. Of these, 4 died (80%).
The team also found that none of the 9 patients without biopsy complications was in an acute sickling crisis at the time of biopsy. However 4 of 5 patients with complications were in acute sickling crisis.
Of the 5 patients with complications, 4 underwent biopsy for an emergency indication.
Researchers determined that chronic venous outflow obstruction, marked hepatic sequestration of erythrocytes, and sinusoidal dilatation were strongly associated with complications.
Furthermore, data obtained by biopsy in group 1 were not of substantial value in clinical management, in contrast to group 2.
Dr Nada Zakaria's team concluded, "Acute hepatic disease complicating sickle cell anemia represents a newly identified contraindication to percutaneous liver biopsy".