Esophageal acid neutralization with antacids depends on both the duration of esophageal antacid exposure, and the acid neutralizing capacity.
A gum that releases antacid as it is chewed could take advantage of these mechanisms to enhance heartburn relief.
In this study, researchers from the United States crossed over 24 subjects to 4 regimens. These were placebo, chewable antacid tablets (1000 mg CaCO3), lower dose gum (600 mg CaCO3), and higher dose gum (900 mg CaCO3).
The research team placed a dual pH probe, subjects then ate a standardized provocative meal, and self-dosed once as needed.
|Higher dose gum decreased heartburn more than chewable antacids.|
|Alimentary Pharmacology and Therapeutics|
Their symptoms were recorded every 15 min using visual analogue and Likert scales.
The team found that both gums decreased heartburn symptoms for 120 minutes, when compared to the placebo.
The higher dose gum decreased heartburn more than chewable antacids, up to 120 minutes post-dose.
In addition, active chewable antacid and gums immediately increased esophageal pH, with a significant improvement 15 to 30 minutes post-dose.
The team found that both gums promptly decreased heartburn and elevated esophageal pH. They also provided sustained relief for 120 min.
Furthermore, antacid gums provided faster and more prolonged symptom relief and pH control than chewable antacids.
Dr Collings's team concluded, "Calcium carbonate gum effectively neutralizes esophageal acidity and relieves symptoms following a meal, and is superior to chewable antacids in terms of the duration of heartburn relief".