A team from the University of Manitoba and Manitoba Health, Manitoba, Canada determined whether patients with inflammatory bowel disease have increased incidence of fracture, due to the associated high prevalence of osteopenia.
Patients with inflammatory bowel disease in the University of Manitoba IBD Database (n = 6027) were matched to 10 randomly-selected persons in the general population without inflammatory bowel disease (n = 60 270), by year, age, sex, and postal area of residence.
The incidence of hospitalization for hip fracture was determined on the basis of hospital discharge abstracts. Outpatient medical billing records and hospital discharge abstracts were used to calculate the incidence of spine, rib, and forearm fractures.
Fracture incidence in IBD patients is 40% greater than general population.
Patients with inflammatory bowel disease were found to have significantly increased incidence of fractures at the spine (incidence rate ratio [IRR], 1.74). They also had increased incidence of fractures at the hip (IRR, 1.59), wrist/forearm (IRR, 1.33), and rib (IRR, 1.25), and of any of these fractures (IRR, 1.41).
The authors calculated that the incidence of fracture among persons with inflammatory bowel disease is 40% greater than that in the general population.