Age-standardized mortality rates for hepatocellular carcinoma is increasing in several countries, however, in England and Wales an increase in mortality rates from intrahepatic cholangiocarcinoma has been reported.
Trends in cholangiocarcinoma in most other industrialized countries are unknown.
In this study, published in the December issue of the Journal of Hepatology, a research team analyzed hepatobiliary and pancreatic tumor mortality data, from the United States, Japan, Australia and Europe.
The team examined the World Health Organization mortality database.
|Mortality for intrahepatic cholangiocarcinoma had increased in men in all countries studied.|
|Journal of Hepatology|
They obtained age-standardized mortality rates for men and women, for subcategories of liver tumors, tumors of the gall bladder, extrahepatic biliary tree, and pancreas, from 1979 to 1998.
The researchers confirmed previously reported increases in hepatocellular carcinoma, however, also found increases in other countries, particularly Australia.
Furthermore, the team found that mortality for intrahepatic cholangiocarcinoma had increased in men in all countries studied.
The largest increases where in Australia, and England and Wales.
Dr Shahid Khan's team concluded, "We present a hitherto unreported rise in age-standardized mortality rates from intrahepatic cholangiocarcinoma across 4 continents".
"The cause remains uncertain".
"An impact on the observed trends of improved diagnostic techniques and death certificate misclassification cannot be completely ruled out".
"Future research should include epidemiological studies to examine possible case-clustering and investigation of potential etiological and host factors".