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 19 February 2018

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News

HIV-1 disease progression in individuals with hemophilia coinfected with HCV

Low concentrations of albumin in individuals infected with HIV-1 may indicate a poor outlook and should prompt concern at any stage of infection, find researchers in the latest issue of the Lancet.

News image

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Low serum albumin concentration is associated with short-term survival in individuals with HIV-1.

However, it is unknown whether individuals with a low serum albumin concentration have delayed progression to AIDS, or survive in the long term.

Albumin not associated with progression to AIDS, but strongly associated with death in the short term.
Lancet

In this study, a team of researchers from London, England, assessed the relation between markers of liver function, and progression to AIDS and death, in individuals with hemophilia infected with HIV-1 and hepatitis C virus.

The team measured markers of liver function, and also took CD4 counts every 3 months, in 111 patients at the Royal Free Hospital Haemophilia Centre, London.

In addition, they measured HIV RNA concentrations yearly and then every 3 to 6 months from 1996.

The research team used Cox's regression models to assess the independent prognostic value of these markers for AIDS and death.

The team found that as a fixed covariate, albumin concentrations measured shortly after HIV-1 seroconversion were associated with risk of AIDS (relative hazard 0·91) and death (0·89) over a 15-year period.

These findings were independent of the CD4 count and HIV-1 RNA concentration.

The researchers determined that, as a time-updated covariate (after adjustment for CD4 count and HIV-1 RNA concentrations), albumin was not associated with progression to AIDS (0·96), but was strongly associated with death (0·88) in the short term.

Dr Caroline Sabin's team concluded, "Low concentrations of albumin in individuals infected with HIV-1 could indicate a poor outlook and should therefore prompt concern at any stage of infection".

Lancet 2002; 360: 1546-51
19 November 2002

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