In this study, a team of researchers retrospectively evaluated surgical treatment of hepatocellular carcinoma (HCC), and examined the early and long-term results of 46 hepatic resections.
The team observed 88 patients with HCC.
Of these patients, 57% had been operated, but only 92% of these could be resected.
In addition, 94% of patients had liver cirrhosis.
|Hospital mortality in non-anatomical and anatomical resection subgroups was 4% and 17%, respectively.|
|European Journal of Surgical Oncology|
The team performed 28 non-anatomical resections and 18 anatomical resections.
Tumor clearance at resection margin of at least 1 cm was considered for curative resections.
The research team found overall mortality and morbidity to be 9% and 30%, respectively.
They determined that outcomes improved in recent years, with no hospital mortality recorded between 1995 and 2000.
In addition, hospital mortality among non-anatomical and anatomical resection subgroups was 4% and 17%, respectively.
However, 19 patients suffered recurrences, after a median of 41 months, in 84% of these recurrence was intrahepatic.
The team observed 3-, 5- and 10-year actuarial survival rates to be 62%, 51% and 23%, respectively.
Long-term survival significantly differed between non-anatomical and anatomical resections, with 5-year and 10-year values of 61% and 34% versus 38% and 19%, respectively.
Dr Ziparo's team concluded, "Early results after hepatic resection for HCC can be improved by using a limited surgical approach".
However, "Long-term results are still unsatisfactory, because of the high recurrence rate that is not influenced by different surgical approaches".