In Crohn's disease, cases of interstitial nephritis with renal failure have been reported in connection with the use of mesalamine.
In this study, a team of researchers from France observed 4 patients with severe interstitial nephritis proven by examination of kidney biopsy specimens.
The team discovered renal failure either before, or simultaneously with, the diagnosis of Crohn's disease.
However, patients were not treated with mesalamine.
|Renal function progressed to end-stage renal failure in 3 of the 4 patients.
Impairment of renal function progressed to end-stage renal failure in 3 of the 4 patients.
The research team identified the kidney as an extraintestinal target of Crohn's disease.
Dr Hassane Izzedine's team concluded, "Several unanswered questions remain concerning the frequency of interstitial nephritis in patients with Crohn's disease, as well as the exact role of mesalamine in the development of chronic interstitial nephritis".