In this study, published in the November issue of Colorectal Disease, researchers assessed histological changes in patients with severe ulcerative colitis (UC).
The research team compared histological sections from patients who had received intravenous cyclosporin (Cy) and steroids, and from those treated with intravenous steroids alone.
The Cy group consisted of 23 colectomy specimens, within this a subgroup of 11 pre-Cy histological sections was also available. The control group (steroid-only) contained 10 colectomy specimens.
The team scored biopsies for their histological disease activity (HDAI), villous architecture, and epithelial regeneration.
|Patients showed a 63% increase in villous score post-cyclosporin.|
The HDAI was used to assess the degree of acute and chronic inflammation.
The researchers found the post-Cy group had higher median scores for villous architecture and epithelial regeneration, compared to the pre-Cy and control groups.
In addition, where both pre- and post-Cy histological sections were available, 63% showed increased villous scores and 82% showed increased epithelial regeneration scores, post-Cy.
Dr Hyde's team, from the John Radcliffe Hospital, Oxford, concluded, "Villous transformation and epithelial regeneration…are more frequent and more severe in those patients who received intravenous Cy and steroids, compared to controls who received steroids alone".
Furthermore, "These histological changes may mimic dysplasia".