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 20 April 2018

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News

Growth slowing after acute Helicobacter pylori infection is age-dependent

Helicobacter pylori seroconversion is associated with a slowing of weight gain in children aged 2 years or older, find researchers in the latest issue of the Journal of Pediatric Gastroenterology and Nutrition.

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Most Helicobacter pylori infections occur during childhood, but the health effects of childhood infection are poorly understood.

In this study, a team of researchers from the United States and Peru investigated whether growth decreases in the 2 months after acute H. pylori seroconversion.

The team performed a nested case-control study among children 6 months to 12 years of age in a community on the outskirts of Lima, Peru.

Health interviews were completed daily and anthropometric measurements were taken monthly.

H. pylori infection attenuates weight gain in children aged 2 years or older, only.
Journal of Pediatric Gastroenterology and Nutrition

The team also collected sera every 4 months to test for H. pylori immunoglobulin G.

They compared 2-month height and weight gains of seroconverters with the gains of sex, age, and size-matched seronegative controls.

The researchers found that in the 2 months after H. pylori infection, 26 seroconverters gained a median of 24% less weight than 26 matched controls.

Multivariate analysis revealed that H. pylori infection attenuated weight gain in children aged 2 years or older, only. This decrease was not explained by increased diarrhea.

Dr Douglas Passaro's team concluded that, "H. pylori seroconversion is associated with a slowing of weight gain in children aged 2 years or older".

They added that the, "Reasons for this finding merit additional study".

J Pediatr Gastroenterol Nutr 2002; 35(4): 522-6
22 October 2002

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