The role of Helicobacter pylori infection in nonulcer dyspepsia remains controversial and studies exploring the effect of H. pylori eradication on symptoms have reported conflicting results.
This study, published in the October issue of Helicobacter, used a randomized placebo controlled trial to determine the effect of H. pylori eradication on symptoms in nonulcer dyspepsia.
The research team used a validated symptom questionnaire and 5-year follow up to determine effects.
|5-year follow up found a significant difference between H. pylori negative and positive patients.
Of the 100 patients in the study, 64 were reviewed at 5 years.
The team found a significant difference between patients who were H. pylori negative, and those who remained positive.
Differences were identified with regard to complete symptom resolution, consumption of relevant medications, and peptic ulcer disease development.
There was a trend for gradual symptom improvement over time irrespective of H. pylori status, which may reflect the natural history of this condition.
Researchers also found that for those who remained symptomatic at 5 years, there was no difference in symptom severity based on H. pylori status.
Dr McNamara's team concluded, "The findings of this study support the use of H. pylori eradication in symptomatic patients with nonulcer dyspepsia both to induce symptom resolution and to prevent disease progression".