The researchers investigated the long-term effects of H. pylori cure on gastric morpho-functional parameters in patients with atrophic body gastritis.
They published the results in the October issue of Alimentary Pharmacology & Therapeutics.
A total of 40 patients with atrophic body gastritis were cured of H. pylori infection.
Gastroscopy with biopsies, and gastrin and pepsinogen I levels were evaluated before and 6-12 months after treatment. Basal and stimulated acid secretion was also assessed.
At eradication assessment, body atrophy was no longer observed in 8 of 40 patients.
However, in 32 of the 40 it remained substantially unchanged.
| Gastrinemia decreased significantly in patients with reversed body atrophy.
| Alimentary Pharmacology & Therapeutics |
In the 8 patients with reversed body atrophy, gastrinemia decreased significantly, with respect to the pre-treatment values (265 vs 52 pg/ml).
Furthermore, basal and stimulated acid secretion increased significantly after cure.
In the 32 individuals still presenting body atrophy, gastrinemia was similar to pre-treatment values (457 vs 335 pg/ml).
At follow up (21-25 and 32-70 months), the 8 patients with reversed body atrophy continued with normal gastrinemia (35 vs 39 pg/ml).
However, in the 19 patients with continued atrophy, both corporal atrophy and intestinal metaplasia remained substantially unchanged.
Dr Bruno Annibale, of the University La Sapienza, Rome, concluded on behalf of his colleagues, "Following successful treatment in patients with atrophic body gastritis and H. pylori infection, long-term histological investigations are crucial in order to detect reversed body damage or to confirm continued body atrophy."