A team from Cambridge, England, investigated the association between self-reported birth weight and subsequent risk of colorectal cancer.
Participants were drawn from the European Prospective Investigation of Cancer in Norfolk study, and were aged between 45 and 79 years.
A total of 4532 men and 7325 women, who reported their birth weight, were followed up between 1993 and 1999.
The association between self-reported birth weight and risk of incident colorectal cancer was found to be nonlinear.
| J-shape relation between birth weight and colorectal cancer risk.
| Cancer Epidemiology Biomarkers & Prevention |
Relative to individuals born weighing 2500-3249 g, the adjusted hazard ratio for people born with neonatal macrosomia was 2.57.
There was also some evidence that low birth weight babies were at increased risk of colorectal cancer relative to the referent category.
These risks were essentially unaltered after adjustment for potential confounders.
Author Manjinder S. Sandhu, of the University of Cambridge School of Clinical Medicine, concluded on behalf of fellow colleagues, "There is a J-shape relation between self-reported birth weight and subsequent risk of colorectal cancer.
"Babies born with macrosomia appear to have the greatest risk."