Previous studies have revealed that bone marrow cells have the potential to differentiate into a variety of cell types.
Epithelial cells of male donor origin were distributed in every part of the GI tract of female bone marrow transplant recipients.
| Bone marrow-derived cells have potential to repair severely damaged epithelia.
| Nature Medicine |
The research, published in September's Nature Medicine, found that donor-derived epithelial cells substantially repopulated the GI tract during epithelial regeneration after graft-versus-host disease or ulcer formation.
Author Ryuichi Okamoto, of the Tokyo Medical and Dental University, Yushima, concluded on behalf of the group, "Regeneration of GI epithelia with donor-derived cells in humans shows a potential clinical application of bone marrow-derived cells for repairing severely damaged epithelia, not only in the GI tract but also in other tissues."