The authors evaluated the outcomes of donors in adult-to-adult living donor liver transplantation (LD-LTx), and reported their results in the September issue of Liver Transplantation.
Potential donors underwent a comprehensive multistep evaluation protocol to exclude any conditions that could lead to an increased operative risk.
Follow-up investigations were performed after 6 and 12 months.
Liver regeneration was assessed by computed tomography scan and magnetic resonance imaging scan.
Quality of life (QOL) was investigated according to the Anamnestic Comparative Self-Assessment Scale (ACSA) before donation, and 6 and 12 months after donation.
As of December 2001, 43 right lobe living donations were performed at the Charité, Campus Virchow, Berlin.
None of the donors died or has suffered life-threatening or persisting complications. All patients recovered completely.
| Complications occurred in 18% of donors.
| Liver Transplantation |
The researchers found that complications occurred in 18% of the donors.
The incidence of perioperative surgical complications was 9%, comprising temporary biliary leakages (6.8%), as well as postoperative bleeding (2.2%).
Liver volume regeneration approximated 72% of predonation volume by 6 months and 85% by 12 months.
There was no evidence of significant psychological impairment after donation.
It was discovered that QOL increased after donation, compared with the preoperative state.
Dr Andreas Pascher said on behalf of fellow authors, "In our experience, LD-LTx has proven to be a practicable and safe procedure."
"However, there is a considerable risk of postoperative complications. The donor selection process plays a pivotal role in preventing such complications," Dr Pascher added.
"The discussion of potential risks, especially potential life-threatening risks, must be an integral part of informed consent," it was concluded.