The researchers determined the effect of total colonic dye spray on adenoma detection during routine colonoscopy, and reported their findings in the September issue of Gastrointestinal Endoscopy.
A total of 259 consecutive outpatients undergoing routine colonoscopy were enrolled in the trial.
They were randomized to a dye-spray group (0.1% indigo carmine used to coat the entire colon during withdrawal from the cecum, n = 124) or control group (no dye, n = 135).
Demographics, indication for colonoscopy, and quality of the preparation were similar between the groups.
Extubation from the cecum took a median of 9.0 minutes in the dye-spray group versus 4.5 minutes in the control group.
|Dye-spray identified more:|
- Diminutive adenomas
- Patients with ≥ 3 adenomas
- Non-neoplastic polyps
| Gastrointestinal Endoscopy |
The investigators found that the proportion of patients with at least 1 adenoma and the total number of adenomas were not different between groups.
However, in the dye-spray group significantly more diminutive adenomas (< 5 mm) were detected proximal to the sigmoid colon. In addition, more patients were identified with 3 or more adenomas.
Furthermore, more non-neoplastic polyps were detected throughout the colon in the dye-spray group.
There were no complications reported.
Author Jim C. Brooker, of St Mark's Hospital, London, concluded on behalf of his group, "Dye-spray increases the detection of small adenomas in the proximal colon and patients with multiple adenomas.
"However, long-term outcomes should be studied to determine the clinical value of these findings."