Help
Subscribe


GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy

 20 November 2017

Advanced search
GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy Profile of Roy Pounder

Home

News  
Journals
Review Articles
Slide Atlas
Video Clips
Online Books
Advanced Digestive Endoscopy
Classical Cases
Conference Diary
PubMed
International GH Links
USA GH Links
National GH Links
National GI Societies
Other Useful Links




Emails on Gastroenterology and Hepatology
the National AIDS Treatment Advocacy Project
Visit the gastroenterology section of the EUMS

News

Worrying rise in deaths from alcoholic liver disease in the UK

Deaths from alcoholic liver disease have increased in the West Midlands region of the UK, reflecting a nationwide trend, suggest researchers in the latest issue of the British Medical Journal.

News image

fiogf49gjkf04

Mortality rates due to cirrhosis and other liver diseases are known to have increased slowly between the 1970s and the early 1990s in the United Kingdom, with the poor prognosis associated with advanced liver failure meaning that its prevalence may be reflected by mortality statistics.

Using this fact, researchers from health centers in the West Midlands region of the UK examined public health mortality files, supplied by the Office for National Statistics, to ascertain the current mortality rates from liver disease in that part of the country.

The study was set in three adjacent metropolitan boroughs in the West Midlands with a total population of 837,000.

Approximately 8.4% of the study population were of south Asian origin (Indian, Pakistani, or Bangladeshi).

The research team identified deaths from liver disease by searching the public health mortality records using ICD-9 (International Classification of Diseases, 9th revision) reference codes 570-573.

South Asian origin and religion were identified from subjects' names.

In incidences of deaths from liver disease of unspecified cause, the case notes of the subject were analyzed to identify underlying causative factors.

Crude mortality from primary liver disease was found to have increased from 6.0 per 100,000 population in 1993, to 12.7 per 100,000 population in 2000.

During the same period, rates of alcoholic liver disease increased nearly 3-fold (2.8 deaths/100,000 in 1993 versus 8.0 deaths/100,000 in 2000).

This 3-fold rise in mortality due to alcoholic liver disease could almost exclusively account for the overall rise in crude mortality, even though there was some stabilization in alcoholic liver disease-related deaths from 1998 onwards.

Rates of increase in deaths from alcoholic liver disease were similar for white men, white women, and Asian men.

Asian men had a standardized mortality ratio 3.79 times (3.21 to 4.26) that of white men (based on 46 observed deaths compared with 12.4 expected by extrapolation from the white male population).

80% of the Asian men were judged to be of Sikh religion.

After alcoholic liver disease, the largest cause of death was "unspecified" liver disease, with an annual incidence of 2.5/100 000 population.

Alcohol misuse was the presumed cause in 67% (44) of 66 such cases as judged by analysis of case notes. Annual mortality from other defined liver diseases was about 0.5/100 000.

Commenting on the findings of the survey, the authors say that although the rise in deaths from alcoholic liver disease might be the result of increasing alcohol consumption, available evidence does not show an increase in the total national alcohol consumption in the past decade.

There was a 3-fold rise in alcoholic liver disease-related deaths between 1993 and 2000
British Medical Journal

There is also no data to suggest that the numbers of people drinking heavily has risen over the past 10 years.

They suggest that the type of alcoholic drink being consumed and dietary or other factors, such as genetic or unidentified environmental factors, may therefore be implicated.

The authors add that the increasing prevalence of alcoholic liver disease among Asians may also be contributing, saying that although the overall population of Asians in the study was small, their excess risk of mortality is worth further study.

These data have important implications for public health and hospital physicians. The halting or reversal of the trend in deaths from alcoholic liver disease that we have described requires further public emphasis on the risk of fatal liver disease from excessive alcohol consumption, they conclude.

BMJ 2002; 325(7359): 312-313
12 August 2002

Go to top of page Email this page Email this page to a colleague

 20 November 2017 
Barriers to hepatitis C treatment
 20 November 2017 
Socioeconomic characteristics in diverticular disease
 20 November 2017 
Endoscopic indices of disease activity for Crohn’s
 17 November 2017 
Food elimination diets for treatment of adults with eosinophilic esophagitis
 17 November 2017 
PPI use and cognitive function in women
 17 November 2017 
Predicting microscopic colitis
 16 November 2017 
NAFLD-hepatocellular carcinoma and survival after orthotopic liver transplant
 16 November 2017 
Prepregnancy obesity and severe maternal morbidity
 16 November 2017 
Celiac disease screening in adult first-degree relatives
 15 November 2017 
Breastfeeding and the risk of IBD
 15 November 2017 
Medication nonadherence and health care costs
 15 November 2017 
Predicting recurrence after curative rectal cancer surgery
 14 November 2017 
HBV/HCV coinfection and cirrhosis
 14 November 2017 
Sexual dysfunction after rectal cancer surgery
 14 November 2017 
Eosinophilic gastroenteritis and colitis
 13 November 2017 
GI bleeding in patients taking non–vitamin K antagonist oral anticoagulants
 13 November 2017 
Genetic polymorphisms, fatty acids and ulcerative colitis
 13 November 2017 
Flares after immunomodulator withdrawal in Crohn's
 10 November 2017 
Thiopurines vs TNF and lymphoma risk in IBD
 10 November 2017 
Drug monitoring of anti-tumour necrosis factor therapy in IBD
 10 November 2017 
Treatment decisions for older patients with colorectal cancer
 09 November 2017 
Quality standards in upper gastrointestinal endoscopy
 09 November 2017 
Irradiated rectal cancer and chemoradiotherapy
 09 November 2017 
Environmental factors and IBD
 08 November 2017 
Prophylaxis of spontaneous bacterial peritonitis
 08 November 2017 
Optimal management of postoperative Crohn's disease
 07 November 2017 
Community Screening for Helicobacter pylori
 07 November 2017 
Early readmission in IBD patients
 07 November 2017 
Mesocolic excision for colon cancer
 06 November 2017 
Food elimination diet for children with eosinophilic esophagitis
 06 November 2017 
Biologic agents and obesity in children with IBD
 06 November 2017 
Liver cancer burden despite extensive use of antiviral agents
 03 November 2017 
Statins and mortality in chronic viral hepatitis
 03 November 2017 
Propofol for outpatient colonoscopy
 03 November 2017 
Asthma and IBD development
 02 November 2017 
Diverticulitis and emergency department burden
 02 November 2017 
Rural residence and risk of IBD
 02 November 2017 
Sexual functioning in Hep C
 01 November 2017 
Heartburn relief in adolescents with GERD
 01 November 2017 
Autoimmune pancreatitis in children
 31 October 2017 
Follow-up of positive results on fecal blood tests
 31 October 2017 
Surveillance in ulcerative colitis and Crohn’s disease
 30 October 2017 
Local recurrence after curative rectal cancer surgery
 30 October 2017 
Low-flow ascites pump in refractory cirrhosis
 30 October 2017 
Medical therapy of patients with pediatric-onset IBD
 27 October 2017 
NAFLD in advanced fibrosis in the USA
 27 October 2017 
Early readmission in cirrhosis after bacterial infections
 26 October 2017 
Predicting response to anti-TNF therapy in Crohn's
 26 October 2017 
Conversion to open laparotomy in rectal cancer
 25 October 2017 
Conversion of colonoscopy to sigmoidoscopy
 25 October 2017 
Fecal microbiota transplantation
 25 October 2017 
Rifaximin and survival in hepatic encephalopathy
 24 October 2017 
Eosinophilic esophagitis with swallowed topical corticosteroids
 24 October 2017 
Meta-analysis in nutritiona research
 23 October 2017 
NAFLD-related hepatocellular carcinoma in liver resection
 23 October 2017 
Outcome of hepatic sarcoidosis
 20 October 2017 
Conversion of planned colonoscopy to sigmoidoscopy
 20 October 2017 
Hospital readmissions reduction program
 19 October 2017 
Surgical anastomosis at 1-year colorectal cancer surveillance
 19 October 2017 
Fecal immunochemical tests in colorectal cancer screening

Blackwell Publishing


GastroHep.com is a Blackwell Publishing registered trademark
© 2017 Wiley-Blackwell and GastroHep.com and contributors
Privacy Statement
Disclaimer
About Us