Help
Subscribe


GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy

 25 November 2017

Advanced search
GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy Profile of Roy Pounder

Home

News  
Journals
Review Articles
Slide Atlas
Video Clips
Online Books
Advanced Digestive Endoscopy
Classical Cases
Conference Diary
PubMed
International GH Links
USA GH Links
National GH Links
National GI Societies
Other Useful Links




Emails on Gastroenterology and Hepatology
the National AIDS Treatment Advocacy Project
Visit the gastroenterology section of the EUMS

News

Helicobacter pylori status of the partner is not important in reinfection of eradicated patients

The importance of the role played by the partners of patients in reinfection following Helicobacter pylori eradication has been tested in a study from Madrid, Spain.

News image

fiogf49gjkf04

An evaluation of whether the Helicobacter pylori status of the patient's partner is important in reinfection after eradication success has been published in the August issue of The European Journal of Gastroenterology and Hepatology.

The research group that conducted the study also attempted to assess the possibility of testing for transmission of H. pylori among partners by using molecular methods.

A total of 120 patients in whom H. pylori had been eradicated were studied prospectively.

Endoscopy with biopsies and a 13C-urea breath test were performed 1 month after completing therapy.

The breath test was repeated in all patients at 6 and 12 months.

At the 1-year follow-up visit (or before if reinfection occurred), a breath test was also performed on the patient's partner.

Gastric biopsies from patients and gastric content obtained by the string test from partners was used in order to conduct the molecular study.

UreC, a product of the UreC gene, was obtained by enzymatic digestion with MseI and HhaI enzymes of a polymerase chain reaction (PCR) product of 1179 base pairs.

H. pylori recurrence:
Partner infected - 7.6%
Partner not infected - 3.6%
Eur J Gastroenterol Hepatol

The researchers then examined the heterogeneity of ureC using electrophoresis to generate different band patterns.

Reinfections were diagnosed in 4 patients at 6 months, and a further 4 from 6 to 12 months, producing an incidence rate of 6.8% per patient-year.

Of these reinfected patients, 87% (7 out of the eight) had partners who were H. pylori-positive.

However, there was also a high prevalence (76%) of H. pylori infection in the partners of patients that did not become reinfected following eradication therapy.

Following multivariate analysis, age of the patient, δ13CO2 value after therapy, and therapy regimen, were the only variables that correlated with H. pylori recurrence.

In contrast, family variables (H. pylori status of partner, breath test value of partner, length of time couple had lived together, number of children living at home, and household density) did not correlate with recurrence of infection.

H. pylori recurrence occurred in 7 of 92 (7.6%) patients when the partner was infected and in 1 of 28 (3.6%) patients when the partner was H. pylori-negative.

Therefore, even if the spouse was infected, 92.4% of patients remained uninfected 1 year after H. pylori eradication.

The molecular study revealed that H. pylori strains involved were different in all cases.

Concluding, the authors of the report observe that recurrence of H. pylori infection seems to be relatively infrequent, even if the patient's spouse is H. pylori-positive.

They add that the molecular study demonstrates that the strains in reinfected patients and their partners are different, suggesting that the patient's partner does not act as a reservoir for H. pylori reinfection.

Eur J Gastroenterol Hepatol 2002; 14(8): 865-871
09 August 2002

Go to top of page Email this page Email this page to a colleague

 24 November 2017 
Osteoporotic fractures in Barrett's esophagus
 24 November 2017 
Center ERCP volume and procedure success
 24 November 2017 
Adipokines and IBD
 23 November 2017 
Pharmacological management of GERD
 23 November 2017 
Incidence of biopsy-verified celiac disease
 23 November 2017 
Distance travelling for rectal cancer outcomes
 22 November 2017 
Challenges of US-trained gastroenterologists when abroad
 22 November 2017 
Surgical treatment delays influence survival in colon cancer
 22 November 2017 
Golimumab in Crohn's disease
 21 November 2017 
Preoperative optimization in IBD patients
 21 November 2017 
Cholangiopathy in critically ill patients
 21 November 2017 
Prepregnancy obesity and maternal mortality
 20 November 2017 
Barriers to hepatitis C treatment
 20 November 2017 
Socioeconomic characteristics in diverticular disease
 20 November 2017 
Endoscopic indices of disease activity for Crohn’s
 17 November 2017 
Food elimination diets for treatment of adults with eosinophilic esophagitis
 17 November 2017 
PPI use and cognitive function in women
 17 November 2017 
Predicting microscopic colitis
 16 November 2017 
NAFLD-hepatocellular carcinoma and survival after orthotopic liver transplant
 16 November 2017 
Prepregnancy obesity and severe maternal morbidity
 16 November 2017 
Celiac disease screening in adult first-degree relatives
 15 November 2017 
Breastfeeding and the risk of IBD
 15 November 2017 
Predicting recurrence after curative rectal cancer surgery
 15 November 2017 
Medication nonadherence and health care costs
 14 November 2017 
Eosinophilic gastroenteritis and colitis
 14 November 2017 
HBV/HCV coinfection and cirrhosis
 14 November 2017 
Sexual dysfunction after rectal cancer surgery
 13 November 2017 
Genetic polymorphisms, fatty acids and ulcerative colitis
 13 November 2017 
Flares after immunomodulator withdrawal in Crohn's
 13 November 2017 
GI bleeding in patients taking non–vitamin K antagonist oral anticoagulants
 10 November 2017 
Thiopurines vs TNF and lymphoma risk in IBD
 10 November 2017 
Drug monitoring of anti-tumour necrosis factor therapy in IBD
 10 November 2017 
Treatment decisions for older patients with colorectal cancer
 09 November 2017 
Quality standards in upper gastrointestinal endoscopy
 09 November 2017 
Irradiated rectal cancer and chemoradiotherapy
 09 November 2017 
Environmental factors and IBD
 08 November 2017 
Prophylaxis of spontaneous bacterial peritonitis
 08 November 2017 
Optimal management of postoperative Crohn's disease
 07 November 2017 
Community Screening for Helicobacter pylori
 07 November 2017 
Early readmission in IBD patients
 07 November 2017 
Mesocolic excision for colon cancer
 06 November 2017 
Food elimination diet for children with eosinophilic esophagitis
 06 November 2017 
Biologic agents and obesity in children with IBD
 06 November 2017 
Liver cancer burden despite extensive use of antiviral agents
 03 November 2017 
Statins and mortality in chronic viral hepatitis
 03 November 2017 
Propofol for outpatient colonoscopy
 03 November 2017 
Asthma and IBD development
 02 November 2017 
Diverticulitis and emergency department burden
 02 November 2017 
Rural residence and risk of IBD
 02 November 2017 
Sexual functioning in Hep C
 01 November 2017 
Autoimmune pancreatitis in children
 01 November 2017 
Heartburn relief in adolescents with GERD
 31 October 2017 
Follow-up of positive results on fecal blood tests
 31 October 2017 
Surveillance in ulcerative colitis and Crohn’s disease
 30 October 2017 
Local recurrence after curative rectal cancer surgery
 30 October 2017 
Low-flow ascites pump in refractory cirrhosis
 30 October 2017 
Medical therapy of patients with pediatric-onset IBD
 27 October 2017 
NAFLD in advanced fibrosis in the USA
 27 October 2017 
Early readmission in cirrhosis after bacterial infections
 26 October 2017 
Predicting response to anti-TNF therapy in Crohn's

Blackwell Publishing


GastroHep.com is a Blackwell Publishing registered trademark
© 2017 Wiley-Blackwell and GastroHep.com and contributors
Privacy Statement
Disclaimer
About Us