The team investigated the association between infection with CagA bearing strains of Helicobacter pylori and risk of coronary heart disease.
They published their findings in the July issue of Heart.
A total of 201 patients (cases) who subsequently had a coronary event during follow up were included in the study. These were matched for age and smoking with 414 individuals (controls) who remained event-free.
H. pylori CagA serological status was determined in plasma samples of the participants using a semi-quantitative commercial enzyme linked immunosorbent assay (ELISA) kit against the p120 antigen of CagA.
It was found that 52% of the patients in the case group and 43% of the controls were seropositive (odds ratio (OR) 1.49).
|Proportion with CagA H. pylori strain:|
CHD patients: 52%
| Heart |
The association remained significant after adjustment for blood pressure, body mass index, plasma concentrations of low-density lipoprotein and high-density lipoprotein cholesterol, history of hypertension and diabetes, statin treatment, and socioeconomic status (OR 1.51).
Baseline inflammatory markers (white cell count, C reactive protein, fibrinogen) were not significantly increased in either H. pylori CagA positive cases or controls.
Author R. K. Singh, of the University of Leicester, said on behalf of the group, "The findings provide support from a prospective study for the hypothesis that there is an association between infection with CagA bearing strains of H. pylori and coronary heart disease."
"The mechanism(s) underlying the association remain to be elucidated," it was concluded.