The team conducted a meta-analysis to compare the risk of colorectal neoplasia in patients with ulcerative colitis (UC), with and without primary sclerosing cholangitis (PSC), and reported their findings in the July issue of Gastrointestinal Endoscopy.
By using MEDLINE and manual search methods, 11 appropriate studies were identified.
| Patients with UC and PSC 5-times more likely to develop neoplasia.
| Gastrointestinal Endoscopy |
Patients with UC and PSC were at increased risk of colorectal dysplasia and carcinoma compared with patients with UC alone. The odds ratios (OR) were 4.79 with the Mantel-Haenszel method, and 5.11 with the Der Simonian and Laird method.
The authors found that this increased risk was present even when the risk of colorectal carcinoma alone was considered; OR 4.09 and 4.26, using the Mantel-Haenszel and the Der Simonian and Laird methods, respectively.
Dr Roy M. Soetikno, of the Palo Alto Veterans Affairs Health Care System, California, said on behalf of his group, "Patients with UC and PSC have a significantly higher risk for the development of colorectal neoplasia than patients with UC alone."
"More intensive colonoscopic surveillance should be considered for patients with UC and PSC, he concluded.