A high prevalence of osteoporosis is reported in inflammatory bowel disease (IBD), and its pathogenesis is not completely resolved.
The Netherlands-based study investigated whether BMD in patients with IBD at diagnosis is lower than in population controls. The study also looked at whether BMD differs between patients with Crohn's disease and those with ulcerative colitis.
68 patients and 68 age- and gender-matched population controls were assessed. BMD of total body, spine, and hip was determined using dual-energy X-ray absorptiometry within 6 months after establishing the diagnosis. Determinants for low BMD were assessed
"Development of osteoporosis in IBD relates to the disease process and/or its treatment." Dr Erik Schoon.
There were no significant differences in BMD (g/cm2) between patients and controls, and no significant differences in BMD between patients with either Crohn's disease or ulcerative colitis.
The team carried out multivariate regression analysis. They found that duration of complaints longer than 6 months before diagnosis (P = 0.041), age (P = 0.019), and body mass index less than 20 kg/m2 (P = 0.006) significantly correlated with a lower BMD.
Erik Schoon concluded on behalf of the group, "Subsequent development of osteoporosis in patients with IBD seems to be a phenomenon related to the disease process and/or the treatment the disease."