A team from Paris, France, assessed the prevalence of fatigue in patients with hepatitis C virus (HCV) infection.
They also identified associations between fatigue and clinical and biological hepatic and extrahepatic manifestations.
Data was prospectively recorded for 1614 patients infected with HCV.
Fatigue was present in 53% of the patients. In 17% of patients, fatigue was severe, impairing activity.
Five extrahepatic manifestations had a prevalence above 10%. These included, in decreasing order, arthralgia, paresthesia, myalgia, pruritus, and sicca syndrome.
|Fatigue in HCV associated with:|
- Female gender
- > 50 years of age
| Journal of Viral Hepatitis |
In univariate and multivariate analyses, fatigue, in comparison with the absence of fatigue, was associated with female gender, age over 50 years, cirrhosis, depression, and purpura.
Independent of these associations, fatigue was associated with arthralgia, myalgia, paresthesia, sicca syndrome, and pruritus.
The prevalence of fibromyalgia (as defined by the association of fatigue with arthralgia or myalgia) was found to be 19%.
There was no significant association between fatigue and the following characteristics: viral load or genotype, alcohol consumption, abnormal thyroid function, and type and level of cryoglobulinemia.
Hence, fatigue is the most frequent extrahepatic manifestation in patients infected with HCV, the authors concluded.