The researchers investigated whether Helicobacter pylori eradication may be beneficial in the management of chronic open-angle glaucoma.
The findings of the study were published in the latest issue of the Archives of Internal Medicine.
A high prevalence of H. pylori infection has previously been documented in patients with glaucoma.
A total of 41 patients with glaucoma and 30 age-matched anemic controls were included in the trial.
All underwent upper gastrointestinal endoscopies and gastric mucosal biopsies to detect the presence of H. pylori infection by histologic analysis and rapid urease test.
The rapid urease test was also used to assess saliva samples.
Serum anti-H. pylori-specific IgG was analyzed by enzyme-linked immunosorbent assay.
|H. pylori eradication improved intraocular pressure and visual field.
| Archives of Internal Medicine |
H. pylori-positive patients received a triple eradication regimen (omeprazole, clarithromycin, and amoxicillin treatment).
All patients were observed for 2 years while remaining under the same antiglaucoma therapy.
H. pylori was detected in 88% of glaucoma cases and in 47% of controls.
H. pylori eradication therapy was successful in 83% of treated patients.
At the 2-year clinical end point, glaucoma parameters (mean intraocular pressure and mean visual field) were improved in the subgroup of patients where H. pylori eradication was successful
However, this was not found to be true in the other patients.
Dr Jannis Kountouras, of the Aristotle University of Thessaloniki, concluded on behalf of the group, "H. pylori eradication may positively influence glaucoma parameters, suggesting a possible causal link between H. pylori and glaucoma."