A team from Sweden investigated the possible association between primary liver cancer (PLC) and kidney cancer (KC).
The researchers recently found that the kidney appeared to be the most common site of an extrahepatic primary malignancy in PLC.
The study included all cases of PLC (n = 14,168) and KC (n = 34,304) reported to the Swedish Cancer Registry, between 1958 and 1995.
Both malignancies were reported in 92 cases.
A Poisson model was used to estimate the hazard function of KC and PLC after the diagnosis of PLC and KC, respectively.
| PLC and KC appear to be parallel phenomena.
| GI Cancer |
The probability that a new cancer will be detected after PLC and KC, respectively, was calculated from the hazard function.
The probability of a new cancer within 1 year after PLC and KC diagnosis, at the age of 70, was 2.05% considering KC and 1.30% considering PLC, respectively.
The corresponding probability of KC and PLC in an individual randomly selected from the population at the age of 70 is 0.056% and 0.024%, respectively.
Jerzy Kaczynski, of Sahlgren's University Hospital, Göteborg, said on behalf of fellow colleagues, "In a low incidence area of PLC, this malignancy and KC seem to be parallel phenomena in many patients."
"This finding may imply an existence of at least one common, unknown etiologic factor for these two cancers," it was concluded.