The team examined dietary factors hypothesized to be associated with exocrine pancreatic cancer, and reported their findings in the American Journal of Epidemiology.
Included in the Finnish cohort were 27,111 male smokers, aged 50-69 years old.
Complete dietary information was available for each subject, as ascertained from a self-administered dietary history questionnaire given at baseline (1985-1988).
A total of 163 individuals developed pancreatic cancer between 1985 -1997.
Cox proportional hazards models were used to estimate smoking- and age-adjusted hazard ratios.
| Over 27,000 male smokers were included in the study.
| American Journal of Epidemiology |
The researchers found that energy-adjusted butter consumption and saturated fat intake were positively associated with pancreatic cancer. The hazard ratios (HR) for highest versus lowest quintile were 1.40 and 1.60, respectively.
Energy intake and energy-adjusted carbohydrate intake were inversely associated with the disease (highest quintile vs lowest: HR = 0.62 and 0.62, respectively).
Rachael Z. Stolzenberg-Solomon, of the National Cancer Institute, Bethesda, Maryland, USA, concluded on behalf of her colleagues, "These results support the hypothesis that a high intake of saturated fat may increase the risk of pancreatic cancer in smokers, while greater intakes of energy and carbohydrate may reduce the risk."