An international group of researchers determined factors involved in atrophic chronic gastritis (ACG) in a European dyspeptic population.
Data concerning sociodemographics, social behavior, biological aspects, diet, and virulence factors of Helicobacter pylori strains were collected in a cross sectional study from 19 European centers in 14 countries.
Dyspeptic H. pylori-positive patients with ACG or non-ACG (NACG) at histology were included in the study.
Two immunoblot tests were used to evaluate Anti-CagA antibodies and one for anti-VacA antibodies.
Of the 451 patients included in the study, 267 were analyzed: 202 had NACG and 65 ACG.
Mean age was 44 years and 63% were women.
|Risk factors for ACG included:|
- Coffee consumption
- Sedative consumption
- Anti-CagA and anti-VacA Abs
Risk factors for atrophy identified by multivariate analysis were age over 60 years (Odds ratio [OR] 4.14), coffee consumption (OR 2.35), sedative consumption (OR 2.17), and harboring anti-CagA and anti-VacA antibodies simultaneously (OR 3.09),
The investigators found that the odds were significantly reduced for those with an anxiety score of 6 or more (OR 0.45).
Dr N. Broutet, of the Victor Segalen Bordeaux 2 University, Bordeaux, France, said on behalf of fellow authors, "The simultaneous presence of anti-CagA and anti-VacA antibodies enhanced the risk of ACG in European dyspeptic patients."
"Failure to discern diet and family history as risk factors for ACG may suggest that diet is homogeneous in Europe and that most of the risk factors for ACG identified so far are identical to risk factors for H. pylori infection," it was concluded.