American researchers examined the association between fruit and vegetable intakes and colorectal cancer.
Between 1987 and 1989, 45,490 women with no history of colorectal cancer completed a 62-item Block-National Cancer Institute food-frequency questionnaire.
During 386,142 person-years of follow-up, 314 women reported incident colorectal cancer.
| Almost 45,500 women included in the study.
| American Journal of Clinical Nutrition |
Searches of the National Death Index identified 106 additional cases of colorectal cancer.
A match with state registries identified another 65 colorectal cancers for a total of 485 cases.
Relative risks for increasing quintile of fruit consumption indicated no significant association with colorectal cancer.
For vegetable consumption, there was also no significant association in the multivariate nutrient-density model with increasing quintiles of consumption.
Additionally, 3 alternative models of energy adjustment showed no significant association between increases in vegetable intake and the risk of colorectal cancer.
Andrew Flood, of the the National Cancer Institute, Bethesda, Maryland, concluded on behalf of his colleagues, "Although the limitations of our study design and data merit consideration, this investigation provides little evidence of an association between fruit and vegetable intakes and colorectal cancer."