Help
Subscribe


GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy

 22 February 2018

Advanced search
GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy Profile of Roy Pounder

Home

News  
Journals
Review Articles
Slide Atlas
Video Clips
Online Books
Advanced Digestive Endoscopy
Classical Cases
Conference Diary
PubMed
International GH Links
USA GH Links
National GH Links
National GI Societies
Other Useful Links




Emails on Gastroenterology and Hepatology
the National AIDS Treatment Advocacy Project
Visit the gastroenterology section of the EUMS

News

Scientists point way to screening for inherited stomach cancer

Genetic screening could soon offer hope for families affected by hereditary diffuse gastric cancer, following research published this week by international researchers.

News image

fiogf49gjkf04

Researchers have found that the rare form of stomach cancer - affecting 200 people in the UK each year - is often caused by the inheritance of a faulty gene.

They were able to detect the damaged gene in a third of families with a history of the disease.

The research was published in the May issue of Human Mutation.

Of the 10,500 cases of stomach cancer in the UK each year, about 10% of these run in families.

Dr Carlos Caldas and his team, at the Cancer Research UK Department of Oncology, Cambridge University, studied hereditary diffuse gastric cancer (HDGC).

Researchers looked at 39 families with a history of stomach cancer from 9 different countries, including the UK.

Eleven of the families were affected by HDGC, while the rest had various other inherited types.

Scientists took blood samples from several cancer patients in each family and used them to analyze the E-cadherin gene, which is involved in helping cells bind together in tissues.

When the gene is mutated, cancers like HDGC can develop, in which tumor cells spread rapidly outwards.

Damaged E-cadherin gene in a third of hereditary diffuse gastric cancer patients.
Cancer Research UK

In 4 of the 11 HDGC families, the patients had faulty versions of the E-cadherin gene.

However, none of the patients with other forms of stomach cancer had the fault, suggesting that it is exclusive to this particular type.

Dr Caldas says, "People with a faulty E-cadherin gene have a 60-80% chance of developing stomach cancer at some stage of their life, with many getting it very young.

"It's not an easily treated disease and survival is very poor."

"However, if we can screen for the damaged gene, those affected could have surgery to prevent the disease.

"This may be a difficult option to take, but it's preferable to having a very high chance of dying young from cancer."

Dr Caldas says, "We know that the gene is damaged in about a third of HDGC families, but apparently in none with other forms of inherited stomach cancer.

"That makes it simpler to screen because you've got a self-selecting target group and a high chance of a positive test."

Dr Caldas now intends to extend his research to look at other genes that may increase the risk of stomach cancer.

He hopes that the success of his current work will encourage people with a family history of the disease to volunteer themselves for large-scale clinical studies.

Cancer Research UK
26 April 2002

Go to top of page Email this page Email this page to a colleague

 22 February 2018 
Outcomes with Crohn’s after infliximab withdrawal
 22 February 2018 
Elderly onset of IBD

 22 February 2018 
Autophagy enhancers
 21 February 2018 
Management of hemorrhoids in the USA
 21 February 2018 
Adalimumab and infliximab in biologic-naïve Crohn's
 21 February 2018 
Cystic fibrosis and colorectal cancer
 20 February 2018 
Complications and surveillance colonoscopies
 20 February 2018 
Treatment algorithm for polyp cancers
 20 February 2018 
Predictors of postoperative infection in Crohn's
 19 February 2018 
Screening colonoscopy in the right and left colon
 19 February 2018 
NAFLD prevalence in the USA
 19 February 2018 
Fructans in children with IBS

 16 February 2018 
Inflammatory bowel diseases are global diseases
 16 February 2018 
Undetected celiac in the elderly
 16 February 2018 
Fructans induce non-celiac gluten sensitivity
 15 February 2018 
NSAIDS and GI damage
 15 February 2018 
Oral direct-acting antiviral treatment for Hep C virus genotype 1
 15 February 2018 
Primary vs secondary surgery for the presence of lymph node metastasis
 14 February 2018 
Predicting adenoma detection rate
 14 February 2018 
Normal bowel frequency characterization in the USA 
 13 February 2018 
Personalising treatment options for IBS
 13 February 2018 
Prebiotics improve endothelial dysfunction
 13 February 2018 
Diagnostic criteria for a Rome IV functional gastrointestinal disorders
 12 February 2018 
Visceral hypersensitivity and functional GI disorders
 12 February 2018 
Depression and aggressive IBD
 12 February 2018 
Variability in interpretation of endoscopic findings impacts patient management
 09 February 2018 
Treatment of choice for anastomotic stricture in IBD
 09 February 2018 
PRO measurement information system 
 09 February 2018 
Overall disease severity indices for IBD
 08 February 2018 
Prediction of endoscopically active disease

 08 February 2018 
Steroid-refractory acute severe ulcerative colitis
 08 February 2018 
Decision aid used by IBD patients
 07 February 2018 
Ursodeoxycholic acid combined with bezafibrate for itching
 07 February 2018 
Change in microbiome in gastritis vs gastric carcinoma
 07 February 2018 
Colorectal cancer and primary sclerosing cholangitis-IBD
 06 February 2018 
Risk of death after liver transplantation
 06 February 2018 
Crohn’s disease vs refractory pouchitis
 06 February 2018 
Support for functional dyspepsia symptom diary
 05 February 2018 
Helicobacter spp influence on GI tract 
 05 February 2018 
No link found between severe reflux and all-cause mortality 
 05 February 2018 
Psychological distress in PPI non-responders
 02 February 2018 
Assessing psychosexual impact of IBD
 02 February 2018 
Decrease in overall mortality with cholera vaccination
 02 February 2018 
Diagnostic performance of fecal immunochemical tests
 01 February 2018 
Screening frequency with family histories of colorectal cancer
 01 February 2018 
IBD and sport participation
 01 February 2018 
Life with a stoma 
 31 January 2018 
Aprepitant and gastroparesis 
 31 January 2018 
Anesthesia risk in colonoscopy
 31 January 2018 
GED-0301 for Crohn's Disease
 30 January 2018 
Intestinal dysbiosis and allergic diseases in infants
 30 January 2018 
Fructans and IBS symptoms in children
 29 January 2018 
Dosing calculator for therapy optimization in IBD
 29 January 2018 
Glecaprevir–pibrentasvir for in HCV
 29 January 2018 
Food allergen injections in eosinophilic esophagitis
 29 January 2018 
Reliability of the IBD index
 26 January 2018 
Tofacitinib vs biological therapies for ulcerative colitis
 26 January 2018 
Optimizing selection of biologics in IBD
 26 January 2018 
Nutritional risk and laparoscopic-assisted gastrectomy outcomes
 25 January 2018 
Patient-reported outcome measure for functional dyspepsia

Blackwell Publishing


GastroHep.com is a Blackwell Publishing registered trademark
© 2018 Wiley-Blackwell and GastroHep.com and contributors
Privacy Statement
Disclaimer
About Us