Help
Subscribe


GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy

 20 February 2018

Advanced search
GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy Profile of Roy Pounder

Home

News  
Journals
Review Articles
Slide Atlas
Video Clips
Online Books
Advanced Digestive Endoscopy
Classical Cases
Conference Diary
PubMed
International GH Links
USA GH Links
National GH Links
National GI Societies
Other Useful Links




Emails on Gastroenterology and Hepatology
the National AIDS Treatment Advocacy Project
Visit the gastroenterology section of the EUMS

News

Researchers discover novel form of enteropathy in autistic children

A novel form of enteropathy has been demonstrated in autistic children, which is characterized by epithelial IgG and complement deposition.

News image

fiogf49gjkf04

Researchers from London, England, investigated small intestinal enteropathy in children with regressive autism.

They reported their findings in the latest issue of Molecular Psychiatry.

The investigators, from St Mark's Hospital and the Royal Free & University College Medical School, have previously reported lymphocytic colitis in children with regressive autism, with epithelial damage prominent.

Duodenal biopsies from 25 children with regressive autism were compared to 11 with celiac disease, 5 with cerebral palsy and mental retardation, and 18 histologically normal controls.

The density of intraepithelial and lamina propria lymphocyte populations were determined.

Mucosal immunoglobulin and complement C1q localization were also studied.

IgG deposition seen on basolateral epithelial surface in 92% of autistic children.
Molecular Psychiatry
Standard histopathology showed increased enterocyte and Paneth cell numbers in the autistic children.

Immunohistochemistry demonstrated increased lymphocyte infiltration in both epithelium and lamina propria with upregulated crypt cell proliferation, compared to normal and cerebral palsy controls.

The researchers found that intraepithelial lymphocytes and lamina propria plasma cells were lower than in celiac disease.

However, lamina propria T cell populations were higher, and crypt proliferation similar.

Most strikingly, IgG deposition was seen on the basolateral epithelial surface in 23/25 autistic children, co-localizing with complement C1q.

This was not seen in the other conditions.

Dr F. Torrente, of the Centre for Paediatric Gastroenterology at the Royal Free & University College Medical School, concluded on behalf of fellow colleagues, "These findings demonstrate a novel form of enteropathy in autistic children.

"This is characterized by increases in mucosal lymphocyte density and crypt cell proliferation, which occur with epithelial IgG deposition.

"The features are suggestive of an autoimmune lesion."

In an accompanying Editorial, Julio Licinio and colleagues from the UCLA Laboratory of Pharmacogenomics, in California, USA, comment, "As Torrente et al point out, the data could support different possibilities.

"One such possibility is the concept of local autoimmunity in the gut, leading to altered cognitive functioning by failure to detoxify neuroactive substances originating from the gut.

"The findings would also be consistent with multisystem autoimmunity."

They highlight that there are a number of studies that support Torrente et al's work on an autoimmune basis for autism.

The Editorial authors ask whether these independent findings conclusively support the concept of autoimmunity in autism.

They conclude that, only after various independent replication reports appear, will they be confident that the findings reported in the article are indeed relevant to autism.

Mol Psychiatr 2002; 7: 329, 375-82
25 April 2002

Go to top of page Email this page Email this page to a colleague

 20 February 2018 
Complications and surveillance colonoscopies
 20 February 2018 
Treatment algorithm for polyp cancers
 20 February 2018 
Predictors of postoperative infection in Crohn's
 19 February 2018 
Screening colonoscopy in the right and left colon
 19 February 2018 
NAFLD prevalence in the USA
 19 February 2018 
Fructans in children with IBS

 16 February 2018 
Undetected celiac in the elderly
 16 February 2018 
Inflammatory bowel diseases are global diseases
 16 February 2018 
Fructans induce non-celiac gluten sensitivity
 15 February 2018 
Oral direct-acting antiviral treatment for Hep C virus genotype 1
 15 February 2018 
NSAIDS and GI damage
 15 February 2018 
Primary vs secondary surgery for the presence of lymph node metastasis
 14 February 2018 
Management of hemorrhoids in the USA
 14 February 2018 
Predicting adenoma detection rate
 14 February 2018 
Normal bowel frequency characterization in the USA 
 13 February 2018 
Prebiotics improve endothelial dysfunction
 13 February 2018 
Personalising treatment options for IBS
 13 February 2018 
Diagnostic criteria for a Rome IV functional gastrointestinal disorders
 12 February 2018 
Visceral hypersensitivity and functional GI disorders
 12 February 2018 
Depression and aggressive IBD
 12 February 2018 
Variability in interpretation of endoscopic findings impacts patient management
 09 February 2018 
Treatment of choice for anastomotic stricture in IBD
 09 February 2018 
PRO measurement information system 
 09 February 2018 
Overall disease severity indices for IBD
 08 February 2018 
Prediction of endoscopically active disease

 08 February 2018 
Steroid-refractory acute severe ulcerative colitis
 08 February 2018 
Decision aid used by IBD patients
 07 February 2018 
Ursodeoxycholic acid combined with bezafibrate for itching
 07 February 2018 
Change in microbiome in gastritis vs gastric carcinoma
 07 February 2018 
Colorectal cancer and primary sclerosing cholangitis-IBD
 06 February 2018 
Risk of death after liver transplantation
 06 February 2018 
Crohn’s disease vs refractory pouchitis
 06 February 2018 
Support for functional dyspepsia symptom diary
 05 February 2018 
Helicobacter spp influence on GI tract 
 05 February 2018 
No link found between severe reflux and all-cause mortality 
 05 February 2018 
Psychological distress in PPI non-responders
 02 February 2018 
Assessing psychosexual impact of IBD
 02 February 2018 
Decrease in overall mortality with cholera vaccination
 02 February 2018 
Diagnostic performance of fecal immunochemical tests
 01 February 2018 
Screening frequency with family histories of colorectal cancer
 01 February 2018 
IBD and sport participation
 01 February 2018 
Life with a stoma 
 31 January 2018 
Aprepitant and gastroparesis 
 31 January 2018 
Anesthesia risk in colonoscopy
 31 January 2018 
GED-0301 for Crohn's Disease
 30 January 2018 
Intestinal dysbiosis and allergic diseases in infants
 30 January 2018 
Fructans and IBS symptoms in children
 29 January 2018 
Dosing calculator for therapy optimization in IBD
 29 January 2018 
Glecaprevir–pibrentasvir for in HCV
 29 January 2018 
Food allergen injections in eosinophilic esophagitis
 29 January 2018 
Reliability of the IBD index
 26 January 2018 
Tofacitinib vs biological therapies for ulcerative colitis
 26 January 2018 
Optimizing selection of biologics in IBD
 26 January 2018 
Nutritional risk and laparoscopic-assisted gastrectomy outcomes
 25 January 2018 
Patient-reported outcome measure for functional dyspepsia
 25 January 2018 
Predicting intra-abdominal infections after colorectal surgery
 25 January 2018 
Predictors of gastric cancer risk
 24 January 2018 
Risk factors underlying previously undiagnosed cirrhosis
 24 January 2018 
Ethnicity influences phenotype in IBD
 24 January 2018 
Bariatric surgery vs medical obesity treatment

Blackwell Publishing


GastroHep.com is a Blackwell Publishing registered trademark
© 2018 Wiley-Blackwell and GastroHep.com and contributors
Privacy Statement
Disclaimer
About Us