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 24 May 2018

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News

E. coli vaccine patch could prevent travelers' diarrhea

An Escherichia coli vaccine, delivered by a patch, could protect travelers from diarrhea, according to a study reported in the April issue of Infection and Immunity.

News image

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A team from Maryland, USA, evaluated the clinical safety and immunogenicity of a recombinant subunit vaccine against enterotoxigenic Escherichia coli (ETEC), administered transcutaneously.

Some 26 adult volunteers received patches containing the recombinant ETEC colonization factor CS6, either with heat-labile enterotoxin (LT), or patches containing CS6 alone.

The vaccine was administered at 0, 1, and 3 months. Serum antibodies and antibody-secreting cells (ASCs) were assessed.

It was found that there were no responses to CS6 in the absence of LT.

In the groups receiving both CS6 and LT, 68% and 53% were found to have serum anti-CS6 immunoglobulin G (IgG) and IgA, respectively. In addition, 37% and 42% had IgG and IgA anti-CS6 antibody-secreting cells.

All of the volunteers receiving LT had anti-LT IgG and 90% had serum anti-LT IgA. Some 79% and 37% had anti-LT IgG and IgA antibody-secreting cells.

Antigens delivered by a patch induced systemic immune responses.
Infection and Immunity

Delayed-type hypersensitivity, suggesting T-cell responses, was seen in 14 of 19 volunteers receiving both LT and CS6

No delayed-type hypersensitivity was seen in subjects receiving CS6 alone.

Fernando Güereña-Burgueño, of the Naval Medical Research Center, Silver Spring, Maryland, said on behalf of his team, "This study demonstrated that protein antigens delivered by a simple patch could induce significant systemic immune responses, but only in the presence of an adjuvant such as LT."

"The data suggest that an ETEC vaccine for travelers delivered by a patch may be a viable approach worthy of further evaluation," he concluded.

Infect Immun 2002; 70 (4): 1874-80
09 April 2002

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