A team from Barcelona, Spain, studied the relationship between daily alcohol consumption and the result of eradication therapy for Helicobacter pylori.
Some 156 patients with a diagnosis of peptic ulcer or chronic gastritis were enrolled in the clinical trial.
H. pylori infection was confirmed by the urease test, the 14C-urea breath test, IgG serology, or biopsy.
A combination of omeprazole (20 mg twice daily), clarithromycin (500 mg twice daily), and amoxicillin (1000 mg twice daily) was administered for 1 week.
Four to 8 weeks later, a 14C-urea breath test was carried out to confirm eradication.
The researchers also examined the relationship between eradication and age, sex, smoking, length of illness, pathology studied (ulcus or gastritis), and therapeutic compliance.
Eradication was successful in 76% of the patients.
The only variable found to be significantly associated with the result of the therapy was daily alcohol consumption.
| Failure of H. pylori eradication therapy 3-times more likely in alcohol abstainers.
| European Journal of Gastroenterology and Hepatology |
The authors found that there was a higher probability of failure in non-consumers of alcohol (30%) than in consumers (12%) (adjusted OR = 3.2).
It was also discovered that eradication was dose dependent.
Eradication was successful in 70% of abstemious patients (n = 107), rising to 79% in users of 4-16 g of pure ethanol a day (n = 29), and to 100% in users of 18-60 g daily (n = 20).
José M. Baena concluded on behalf of fellow authors, "Daily alcohol consumption appears to have an additive effect in this eradication therapy."