Researchers investigated the clinical course and severity of Crohn's disease in obese patients.
Obesity is unusual in Crohn's disease, and the particularities of the disease in obese patients have not been studied.
A total of 2065 patients were studied retrospectively.
Obesity was defined by a BMI value > 25.0 at disease onset, and > 30.0 at any time during the course of the disease.
Disease characteristics, therapeutic needs, and year-by-year disease activity were determined in patients with and without obesity.
Of the patients enrolled, 62 (3%) were obese.
When compared with non-obese patients, obese patients did not show differences regarding sex, intestinal disease location, and disease behavior.
However, at diagnosis the obese individuals were older (32 vs 28 years) and a larger proportion had anoperineal disease (35 vs 24%).
|Larger proportion of obese Crohn's patients had anoperineal disease.
| Clinical Nutrition |
The 62 obese patients were paired for sex, location of disease at onset, date of birth, and date of diagnosis, with 124 non-obese patients.
It was found that disease severity, assessed by the importance of medical therapy and excisional surgery, did not differ in the two groups.
Nonetheless, time to development of anoperineal abscess or fistula was shorter in obese patients.
Furthermore, obese patients were more prone to develop an active disease (OR 1.50) and to require hospitalization (OR 2.35).
Dr A. Blain concluded on behalf of fellow authors, "Obesity in Crohn's disease is associated with more frequent anoperineal complications and a more marked year-by-year disease activity.
"However, it does not significantly alter the long-term course of the disease."