The researchers assessed the influence of pathological tumor variables on long-term survival in resectable gastric cancer, and reported their findings in the British Journal of Cancer.
They conducted univariate and multivariate analyses of the prognostic value of various pathological and staging factors. This was done on 324 patients entered into a randomized surgical trial for gastric cancer.
In the univariate analysis, tumor stage, nodal status, UICC clinical stage, number of involved nodes, WHO predominant type, mixed Lauren type, and Ming type were all found to have a significant impact on survival.
Tumor differentiation, and lymphocytic and tumor stromal eosinophilic infiltration were also found to have a significant impact.
| Patients with numerous eosinophils had a lower risk of death.
| British Journal of Cancer |
In the multivariate analysis, UICC clinical stage and eosinophilic infiltration were found to have a significant influence.
Risk of death increased for UICC stage II and III patients (Hazard Ratio for stage II compared to stage I = 2.0; Hazard Ratio for stage III compared to stage I = 3.5).
The researchers found that patients with numerous eosinophils had a lower risk of death than those with none did (Hazard Ratio = 0.5).
Professor Sir A. Cuschieri, of the Ninewells Hospital and Medical School, Dundee, Scotland, concluded on behalf of fellow colleagues, "This association between survival and eosinophilic infiltration merits further study."