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 23 May 2018

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News

Increasing frequency of peptic ulcer hemorrhage among older subjects

The frequency of hemorrhage from gastric and duodenal ulcer, among older subjects, has increased in the last 10 years, claims a team from London, England.

News image

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The researchers determined the recent trends in admissions and mortality due to peptic ulcer in England.

They reported their findings in the April issue of Gut.

Prescriptions for ulcer healing drugs, aspirin, non-steroidal anti-inflammatory drugs (NSAID), oral anticoagulants, and selective serotonin reuptake inhibitors (SSRI) were also analyzed.

Data was obtained from the Office of National Statistics and the Statistics Division 1E of the Department of Health

Between 1989/90 and 1998/99, there was a marked rise in admissions for hemorrhage in older patients, particularly from duodenal ulcer.

Perforations from gastric ulcer declined, but perforations from duodenal ulcer increased among men at older ages.

The team found that, since the mid-1980s, mortality has declined in all age groups, except for older women with duodenal ulcer.

Increase in admissions for hemorrhage coincided with rise in certain drug prescriptions.
Gut
The number of prescriptions for histamine H2 receptor antagonists remained constant.

However, those for proton pump inhibitors increased by 5000%, aspirin 75mg by 460%, oral anticoagulants by 200%, and NSAID by 13% between 1990 and 1999.

Since the introduction of SSRI in 1991, it was found that prescriptions have increased 15-fold.

Author J. Higham, of the Office for National Statistics, London, said on behalf of colleagues, "Admission rates for gastric and duodenal ulcer hemorrhage and duodenal ulcer (but not gastric ulcer perforation) increased among older subjects.

"This was over a time when prescriptions for proton pump inhibitors, low dose aspirin, oral anticoagulants, and SSRI increased."

Gut 2002; 50 (4): 460-4
19 March 2002

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