In patients with nonalcoholic steatohepatitis (NASH), age, obesity, and diabetes mellitus are independent predictors of the degree of fibrosis.
When adjusted for sex, the relative risk for fibrosis is also associated with increasing grade of Perls stain.
A new study to determine whether the risk factors for fibrosis described in NASH are also risk factors in alcohol-induced liver disease has now been published in the latest issue of the journal Hepatology.
Bruno Raynard and colleagues looked at 268 alcoholic patients with negative hepatitis B virus and hepatitis C virus serology who underwent liver biopsy.
The research group assessed fibrosis semi-quantitatively, using a score fluctuating between 0 and 8.
Liver iron overload was measured by Perls staining and graded in four classes.
|BMI, Perls grade, and blood glucose:|
Independent factors for fibrosis
A multivariate regression with partial correlation analysis was then used to assess the variability of fibrosis score according to the value of seven variables.
These variables were sex, age, body mass index (BMI) in the past year prior to hospitalization when the patient was asymptomatic, daily alcohol intake over the past five years, total duration of alcohol abuse, Perls grade, and blood glucose level.
In the multivariate regression, fibrosis score was positively correlated with age, BMI, female sex, Perls grade, and blood glucose level.
The seven variables could be used to explain 20% of the variability of fibrosis score.
Speaking on behalf of his fellow authors Dr Raynard said, "Following adjustment for daily alcohol intake and duration of alcohol abuse, BMI, Perls grade, and blood glucose are also independent risk factors for fibrosis in alcohol-induced liver disease."
He finished, " These findings raise therapeutic implications for the management of these patients."