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 23 February 2018

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News

Vaccinating chronic hepatitis C patients against hepatitis A reduces morbidity and mortality

Hepatitis A vaccination of chronic hepatitis C patients would substantially reduce morbidity and mortality in all age groups, according to research published in the February issue of the American Journal of Gastroenterology.

News image

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A team from Alexandria, Virginia, USA, evaluated the cost-effectiveness of vaccinating chronic hepatitis C patients against hepatitis A.

A Markov model was used to assess cost-effectiveness from the health system and societal perspectives.

Costs of hepatitis A screening and vaccination were compared with savings from reduced hepatitis A treatment and work loss. These were used to determine net costs of a "screen and vaccinate" strategy.

The researchers compared net costs with longevity gains, to assess cost-effectiveness.

Based on hypothetical cohorts of 100,000 patients, it was found that vaccination would reduce the number of hepatitis A cases by 63-72%, depending on patient age.

Vaccination would reduce number of hepatitis A cases by 63-72%.
American Journal of Gastroenterology

Screening and vaccination costs of $5.2 million would be partially offset by $1.5-$2.8 million reductions in hepatitis A treatment costs and $0.2-$1.0 million reductions in work loss costs.

From the health system perspective, vaccination would cost $22,256, $50,391, and $102,064 per life-year saved for patients vaccinated at ages 30, 45, and 60 years, respectively.

The team found that cost-effectiveness ratios improved when work loss prevention was considered.

Author R. J. Jacobs, of Capitol Outcomes Research, in Alexandria, said on behalf of the group, "Hepatitis A vaccination of chronic hepatitis C patients would substantially reduce morbidity and mortality in all age groups examined."

"Consistent with other medical interventions for chronic hepatitis C patients, cost-effectiveness is most favorable for younger patients," it was concluded.

Am J Gastroenterol 2002; 97(2): 427-34
05 March 2002

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