Nonsteroidal anti-inflammatory drugs are responsible for 3% to 10% of idiosyncratic drug-induced liver injury cases in the Western world.
Dr Isabel Lucena and colleagues of Spain found that ibuprofen is a widely prescribed nonsteroidal anti-inflammatory drugs available as over-the-counter medication, and perceived as having a better safety profile than many other nonsteroidal anti-inflammatory drugs.
|Ibuprofen is a widely prescribed nonsteroidal anti-inflammatory drug |
|Clinical gastroenterology and Hepatology|
Interestingly, striking regional differences in the frequency of ibuprofen hepatotoxicity were noted in a comparison of causative drug-induced liver injury agents among large cohorts in 2010.
Dr Lucena's team concludes,"Based on the limited information available on this type of drug-induced liver injury, we aimed to analyze the clinical presentation of ibuprofen-associated hepatotoxicity in the search for a potential drug signature."