Inflammatory bowel diseases are global diseases.
Similarities and differences in disease presentation and outcomes across different geographic regions and ethnic groups have not been compared previously.
Dr Siew Ng and colleagues of Hong Kong performed a systematic review and meta-analysis of population-based cohort studies examining the phenotype and outcome of Inflammatory bowel diseases across ethnic groups categorized as Whites, Blacks, Hispanics, and Asians.
Further stratification was performed by migration status.
Pooled proportions of disease location, behavior, medication, and surgery use were calculated by using a random-effects model and compared statistically.
The researchers final analysis included 198 unique studies reporting outcomes on 525,425 Inflammatory bowel diseases patients.
Crohn’s disease in Asians but not other ethnicities demonstrated a strong male predominance.
|Family history of IBD was infrequent in Asian patients.|
|Clinical Gastroenterology & Hepatology|
The research team found that family history of inflammatory bowel diseases was infrequent in Asian patients.
Both Black and Asian Crohn’s disease patients demonstrated perianal involvement more frequently.
The team noted that surgery for both Crohn’s disease and ulcerated colitis was less common in Asians than Caucasians.
Compared with native residents, a family history of Inflammatory bowel diseases was reported more often among immigrant inflammatory bowel diseases patients, but no significant differences were noted in phenotype.
Dr Ng's team concluded, "Significant variation in the demographic distribution is demonstrated, familial predisposition, phenotype, and outcomes of Inflammatory bowel diseases between Caucasians, Blacks, Hispanics, and Asians."
"There is need for further study to understand the biology behind this variation."