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 23 May 2018

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News

Gastrointestinal-patient reported outcome information system holds potential

This month's edition of the American Journal of Gastroenterology identifies gastrointestinal patient reported outcomes measurement information system symptom scales in subjects with inflammatory bowel diseases.

News image

Patient reported outcomes (PRO) are important treatment endpoints in inflammatory bowel diseases.

Dr Millie Long and colleagues from North Carolina, USA, evaluated the gastrointestinal PRO Measurement Information System in inflammatory bowel diseases subjects.

Crohn’s and Colitis Foundation of America’s Partners is an Internet-based cohort of inflammatory bowel diseases subjects.

Participants complete surveys, including demographics, disease characteristics, PRO Measurement Information System domains, disease activity and quality of life indices.

The researchers assessed associations between 8 gastrointestinal-PRO Measurement Information System domains and quality of life and disease activity indices.


Median disease duration was 11 years for Crohn's disease subjects 
American Journal of Gastroenterology
The study included 2,378 Crohn's disease and 1,455 ulcerative colitis respondents with a median age of 41 years.

Median disease duration was 11 years for Crohn's disease subjects and 8 years for ulcerative colitis subjects; 57% of Crohn'sdDisease subjects, and 42% of ulcerative colitis subjects were in remission.

The researchers found that among symptomatic Crohn's disease subjects, those with active Crohn's disease reported significantly worse symptoms on all 8 domains than those in remission.

The team observed that same for ulcerative colitis subjects with the exception of disrupted swallowing.

Inflammatory bowel diseases subjects with worse quality of life reported significantly worse symptoms on all 8 domains compared to those with better quality of life.

Dr Long's team concluded, "In inflammatory bowel diseases subjects experiencing gastrointestinal symptoms, gastrointestinal-PRO Measurement Information System domains were strongly associated with disease activity and quality of life indices."

"Gastrointestinal-PRO Measurement Information System holds potential as patient reported outcomes measures in inflammatory bowel diseases and correlates with other validated indices in this population."

Am J Gastroenterol 2018: 113 (1)
09 February 2018

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