Dr George Stracher and a team from the University of Vienna conducted a study of seventy-one outpatients (37 female, 34 male; age 23-82 years) with symptoms suggestive of both delayed gastric emptying and reflux.
They recorded scintigraphically the gastric emptying of a semisolid 1168 kJ meal and esophageal clearance of a water bolus (supine). They assessed reflux by 24-hour pH monitoring, and measured esophageal motility manometrically.
The Vienna team's findings showed slow proximal (but not slow distal or total) stomach emptying correlated not only with increased 24-hour and postprandial acid exposure, but also an increased number of reflux episodes/hour.
Slow proximal emptying and low LOS pressure contribute to acid reflux.
They found no relationships between total or proximal emptying and LOS resting pressure, esophageal contraction amplitude, percentage of failed contractions, or clearance.
Multiple linear regression analyses showed that slow proximal emptying and low LOS pressure contributed significantly to both 24-hour (p=0.0007 and p=0.0001) and two-hour postprandial acid exposure (p=0.007 and p=0.0001). In contrast, the rate of total emptying contributed to neither 24-hour nor postprandial acid exposure.