Few data are available on adverse events of pregnancy in women with inflammatory bowel diseases (IBD), such as ectopic pregnancy.
Dr Punyanganie de Silva and colleagues from Massachusetts, USA assessed the risk of ectopic pregnancy in pregnancies of women in Denmark with IBD compared with those without IBD over a 22-year period.
The research team also examined the disease-specific risks of ectopic pregnancies in pregnancies of women with ulcerative colitis (UC) or Crohn’s disease (CD) who underwent IBD-related surgical procedures.
The team performed a retrospective study of all women of child-bearing age registered in the Danish National Patient Registry with at least 1 pregnancy during the period from 1994 through 2015.
|Women with CD had a greater risk of ectopic pregnancy,|
|Clinical Gastroenterology & Hepatology|
The research team collected data on all women with an ectopic pregnancy, hydatidiform mole, miscarriages, induced abortions, and births in women with and without IBD.
The team evaluated 7548 pregnancies in women with UC, 6731 pregnancies in women with CD, and 1,832,732 pregnancies in women without IBD.
The researchers controlled for multiple covariates, including pelvic and abdominal surgery.
The team observed that women with CD had a greater risk of ectopic pregnancy, per pregnancy, than women without IBD, whereas women with UC did not.
In pregnancies of women with CD and UC who underwent IBD-related surgery before pregnancy, there was a nonsignificant increase in risk of ectopic pregnancy compared with pregnancies in women with IBD who did not have surgery.
Dr de Silva's team concludes, "We found a statistically significant increased risk of ectopic pregnancy in pregnancies of women with CD compared with pregnancies of women without IBD."
"Surgery for IBD before pregnancy increased the risk of ectopic pregnancy, although this increase was not statistically significant."