Nonalcoholic fatty liver disease, the hepatic manifestation of metabolic syndrome, is associated with increased risk of colorectal adenoma, a precursor of colorectal cancer.
Because nonalcoholic fatty liver disease and colorectal adenoma share many common risk factors of metabolic syndrome, the association between these 2 pathological findings has been investigated in multiple studies, but the results have been conflicting.
Dr Eun Young Ze and colleagues assessed the relationship between the fatty liver index, a predictor of nonalcoholic fatty liver disease, and the prevalence of colorectal adenomas.
|51% had fatty liver on ultrasonography|
|Diseases of the Colon & Rectum|
A total of 2976 consecutive subjects over 40 years of age undergoing routine checkups including abdominal ultrasonography and colonoscopy at Chung-Ang University Hospital Health Care Center were included.
The researchers' primary outcome measured was the prevalence of colorectal adenomas according to fatty liver index.
Among these subjects, 31% had colorectal adenoma, 23% had metabolic syndrome, and 51% had fatty liver on ultrasonography.
The research team found that a fatty liver index ≥30 was associated with an increased risk of colorectal adenoma.
The fatty liver index-high group had more colorectal adenomas and more advanced colorectal adenomas than the fatty liver index-low group.
The team observed that the prevalence of colorectal adenomas increased with increasing quartile of fatty liver index.
Dr Ze's team concludes, "The high fatty liver index may be a useful predictor of colorectal adenoma."