Oxidative stress may be involved in the aetiology of inflammatory bowel disease and whether dietary polyphenols, which possess antioxidants properties, prevent its development is unknown.
Dr Yunxia Lu and colleagues recruited a total of 401,326 men and women aged 20 to 80 years from 8 countries between 1991 and 1998 and at baseline completed validated food frequency questionnaires.
Dietary polyphenol intake was measured using Phenol-Explorer, a database with information on the content of 502 polyphenols.
Incident cases of Crohn's diseases (CD) and ulcerative colitis (UC) were identified during the follow-up period of up to December 2010.
In total, the team identified 110 cases of CD, and 244 with UC.
|Effect modification by smoking in CD was documented with borderline statistical significance|
|Inflammatory Bowel Diseases|
The team matched these to 440 and 976 controls, respectively.
The researchers observed that total polyphenol intake was not associated with CD or UC.
For flavones and CD, there were reduced odds for all quartiles, which were statistically significant for the third, and there was an inverse trend across quartiles.
Similarly, for resveratrol, the team found an inverse association with CD with an inverse trend across quartiles.
No significant associations between subtypes of polyphenols and UC were found.
Effect modification by smoking in CD was documented with borderline statistical significance.
Dr Lu's team concludes, "The data supports a potential role of flavones and resveratrol in the risk of developing CD."
"Future etiological studies should investigate these dietary components, and further examine the potential for residual confounding."